Did you know all statins are NOT the same? Get to know LIVALO®.

When it comes to helping lower your cholesterol levels, we’re in this together.

Learn about LIVALO, how it works, and if it may be right for you.
The Savings Card program was updated 6/6/14 and requires a new card.
To continue receiving savings, download your replacement LIVALO Savings Card* today.*Certain rules and restrictions apply. ELIGIBLE PATIENTS Download a Savings Card

Do you have a LIVALO Savings Card? The LIVALO Savings Card program was recently updated (6/6/14). Eligible patients, please tap here to download your new LIVALO Savings Card* now. *Certain rules and restrictions apply.

LIVALO is a statin medication that, along with a heart-healthy diet, improves overall cholesterol levels.

Are you afraid your statin medication may interact with other medications you are taking?

You may not be aware that taking multiple medications can cause drug interactions because of how the body metabolizes (processes) them.

  • bottle 1 bottle 1 bottle 1
  • bottle 2 bottle 2 bottle 2
  • bottle 3 bottle 3 bottle 3
  • bottle 4 bottle 4 bottle 4
LIVALO is available in 1mg, 2mg, and 4mg tablets. Does not represent actual size of medications.

LIVALO may be less likely to cause some drug interactions because it is metabolized differently in the body than most statin medications.

To understand this difference, it’s important to know how drugs are processed in the body. After you take medication, it gets digested, absorbed, and travels to the liver where your body breaks drugs down.

pill pill pill pill pill
Illustrative view of how medications are dissolved in the stomach in preparation to be absorbed by the body.

This breakdown process in the liver is called drug metabolism

About 75% of all drugs processed in the body, including most statins, share a common metabolic pathway in the liver known as the "CYP450 pathway."

CYP450

To get broken down, drugs attach to receptors. More drug molecules mean more competition for receptors. This competition can cause incomplete breakdown, undesirable effects, and unpredictability in drug levels and activity. This is "drug interaction."

Drug molecules are transformed by receptors (isoenzymes).
  • Other Medication Molecules
  • LIVALO Molecules
  • Receptors (Isoenzymes)

Approximately 25% of all drugs use primarily other pathways to get metabolized (non-CYP450 pathways).

LIVALO is metabolized differently than most statins – it is primarily processed through a non-CYP450 pathway where it is metabolized by specific chemical compounds made by the liver.

Drug molecules are transformed by specific chemical compounds.
  • Other Medication Molecules
  • LIVALO Molecules
  • Chemical Compounds

Because of this difference, some drug interactions may be less likely with LIVALO.

Did you know all statins are NOT the same? Get to know LIVALO®.

When it comes to helping lower your cholesterol levels, we’re in this together.

Learn about LIVALO, how it works, and if it may be right for you.

LIVALO is a statin medication that, along with a heart-healthy diet, improves overall cholesterol levels.

The Savings Card program was updated 6/6/14 and requires a new card.
To continue receiving savings, download your replacement LIVALO Savings Card* today.*Certain rules and restrictions apply. ELIGIBLE PATIENTS Download a Savings Card

Do you have a LIVALO Savings Card? The LIVALO Savings Card program was recently updated (6/6/14). Eligible patients, please tap here to download your new LIVALO Savings Card* now. *Certain rules and restrictions apply.

LIVALO is a statin medication that, along with a heart-healthy diet, improves overall cholesterol levels.

LIVALO may be less likely to cause some drug interactions because it is metabolized differently in the body than most statin medications.

You may not be aware that taking multiple medications can cause potentially harmful drug interactions because of how the body metabolizes (processes) them.

  • pillsLIVALO Molecules
  • pillsOther Medication Molecules
Because LIVALO primarily uses this pathway, some drug interactions may be less likely.
When you take multiple medications, drugs that share the same pathway compete to get broken down – kind of like cars competing for spots in a crowded parking lot. This competition can cause an increase in drug levels in the body and undesirable effects. This is known as a “drug interaction.” Watch this video to learn how LIVALO may be less likely to cause some drug interactions.

Drug interactions with LIVALO:

  • If you are taking cyclosporine, do not take LIVALO.
  • Caution should be taken when using LIVALO in combination with other cholesterol drugs like niacin and fibrates, as this may increase your risk of serious muscle problems.
  • Avoid use with gemfibrozil.
  • Some drugs, like erythromycin and rifampin, may lead to drug interactions and require a lower daily dose of LIVALO when used in combination.

Select Safety Information about your liver and LIVALO:Anyone with active liver disease should not take LIVALO. Serious liver problems have been reported rarely in patients taking statins, including LIVALO. Your doctor should do liver tests before you start, and if you have symptoms of liver problems while you are taking LIVALO. Tell your doctor right away if you feel more tired than usual, have a loss of appetite, upper belly pain, dark-colored urine, or yellowing of the skin or eyes.

LIVALO helps improve important lipid parameters, such as:

  • -Decrease LDL "Bad" cholesterol
  • +Increase HDL "Good" cholesterol
  • -Decrease TG Triglyceride levels
LIVALO lowers LDL "Bad" cholesterol up to 45% (at the 4 mg dose) and up to 39% (at the 2 mg dose) — making LIVALO an effective choice.* Source: LIVALO Prescribing Information.

LIVALO may be an effective option for you.

  • LIVALO® (pitavastatin) tablets 4mg 45%Lowers LDL "Bad" cholesterol up to 45% (at the 4 mg dose)*
  • LIVALO® (pitavastatin) tablets 2mg 39%Lowers LDL "Bad" cholesterol up to 39% (at the 2 mg dose)*
Click Here to get your LIVALO Savings Card Source: LIVALO Prescribing Information.
*Mean % change from baseline.

Things you should know when taking LIVALO.

  • LIVALO is available in 1 mg, 2 mg, and 4 mg tablets. Take LIVALO tablets once a day, every day, at any time, with or without food. Take LIVALO as long as prescribed by your doctor. It's even okay to continue to drink grapefruit juice.
  • Your doctor should do blood tests to check your cholesterol levels before and during your treatment with LIVALO. Your dose of LIVALO may be changed based on these blood test results.
  • Swallow the tablet whole. Do not split, crush, dissolve, or chew.
  • Store LIVALO tablets at room temperature, in a dry place, and out of the reach of children.
  • It is important to tell your doctor about all the medicines you take, including nonprescription medicines, vitamins, or herbal supplements.
  • If you miss a dose of LIVALO, take it as soon as possible. An easy way to remember to take LIVALO daily is to place it where you’ll see it so it can become part of your daily routine.
Click Here for LIVALO's Doctor Discussion Guide LIVALO® (pitavastatin) tablets 1mg LIVALO® (pitavastatin) tablets 2mg LIVALO® (pitavastatin) tablets 4mg

Eligible patients may pay as little as $18 a month for LIVALO*.

Eligible patients may pay as little as $18 month*
Talk to your doctor about LIVALO.

Present your Savings Card along with your prescription to your pharmacy and you may pay less on your prescriptions of LIVALO.

PLEASE SELECT 'YES' IF YOU WOULD LIKE TO RECEIVE INFORMATION AND SAVINGS OFFERS FROM LIVALORX.COM.
READING THE TERMS AND CONDITIONS IS REQUIRED TO SUBMIT THIS FORM.
*Certain rules and restrictions apply. LOCK SECURE – We will not share your information with anyone. *Details: For patients with commercial insurance, the Savings Card will save you on out-of-pocket costs that exceed $18 (up to a maximum of $75) on each 30-day supply for up to 12 LIVALO prescriptions. For patients who receive a 90-day supply, the Savings Card will cover up to a maximum of $225 off. For cash-paying patients, the Savings Card will deduct from your out-of-pocket costs that exceed $18 (up to a maximum of $75) on each 30-day supply for up to 12 LIVALO prescriptions. Use of this Card does not create any obligation or involve any past or future purchase requirement. You are not eligible if prescriptions are paid by any state or other federally funded programs, including, but not limited to Medicare, Medicaid, Medigap, VA, DOD, or TriCare; or where prohibited by law. Please see eligibility criteria, along with offer terms, on the Savings Card. Certain rules and restrictions apply.

Important Safety Information for LIVALO® (pitavastatin) tablets

Who should NOT take LIVALO?
LIVALO is not right for everyone. Do not take LIVALO if:

  • You have a known allergy to LIVALO or any of its ingredients.
  • You have active liver problems, including some abnormal liver test results.
  • You are nursing, pregnant or may become pregnant, as it may harm the baby.
  • You are currently taking cyclosporine or gemfibrozil.

What is the most important information I should know and talk to my doctor about?

  • Call your healthcare provider or get help right away if you experience any symptoms of an allergic reaction, such as rash, itching, or hives.
  • Muscle problems may be an early sign of rare, serious conditions. Tell your doctor right away if you have any unexplained muscle pain, weakness, or tenderness, particularly if accompanied by malaise or fever, or if these muscle signs or symptoms persist after discontinuing LIVALO.
  • Serious liver problems have been reported rarely in patients taking statins, including LIVALO. Your doctor should do liver tests before you start, and if you have symptoms of liver problems while you are taking LIVALO. Tell your healthcare provider right away if you feel more tired than usual, have a loss of appetite, upper belly pain, dark-colored urine, or yellowing of the skin or eyes.
  • Tell your doctor about all your medical conditions and medications you take including nonprescription medicines, vitamins, or herbal supplements.
  • Increases in blood sugar levels have been reported with statins, including LIVALO.
  • Tell your doctor about your alcohol use.

What are the most common side effects of LIVALO?
The most common side effects of LIVALO in clinical studies were:

  • Back pain
  • Constipation
  • Diarrhea
  • Muscle pain
  • Pain in the legs or arms

This is not a complete list of side effects. Talk to your healthcare provider for more information.
You are encouraged to report negative side effects of all drugs to the FDA.
Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

How should I store and take LIVALO?

  • Store LIVALO tablets at room temperature, in a dry place, and out of the reach of children.
  • LIVALO can be taken at any time of day, with or without food.
  • Swallow the tablet whole. Do not split, crush, dissolve, or chew.

Other important information I should know about LIVALO.

  • LIVALO has not been studied to evaluate its effect on reducing heart-related disease or death.
  • LIVALO is available by prescription only.

For additional information, please see the full Prescribing Information.


LIVALO is a registered trademark of the Kowa group of companies.
© Kowa Pharmaceuticals America, Inc. (2014)
All rights reserved. LIV-MT-1507 December 2014

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